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Literature summary for 3.4.22.B74 extracted from
- The SUMO protease SENP6 is a direct regulator of PML nuclear bodies (2010), Mol. Biol. Cell, 22, 78-90.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMO-modified promyelocytic leukemia protein + H2O | Homo sapiens | - |
SUMO + promyelocytic leukemia protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9GZR1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | although SUMO-2/3 chains are the preferred substrate, SENP6 is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3 | Homo sapiens | ? | - |
? | |
| SUMO-modified promyelocytic leukemia protein + H2O | - |
Homo sapiens | SUMO + promyelocytic leukemia protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SENP6 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | depletion of SENP6 results in accumulation of endogenous SUMO-2/3 and SUMO-1 conjugates, and in accumulation of SUMO and promyelocytic leukemia protein in an increased number of promyelocytic leukemia nuclear bodies. Although SENP6 depletion drastically increases the size of promyelocytic leukemia nuclear bodies, the organizational structure of the body is not affected | Homo sapiens |
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Release 2023.1 (January 2023)
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